The ADVANCE Working Group has developed a cross-sectional, epidemiological study that sought to determine the prevalence of hypertension in older people with haemophilia, and to assess potential risk factors for developing hypertension.
It collected demographic and medical data on more than 500 patients with haemophilia over 40 years of age from 16 participating European centres.
The H3 Study suggests that hypertension is prevalent in haemophilia patients to a similar degree as in the background population with age and BMI being major risk factors. The Study also suggests that renal dysfunction was associated with hypertension, but the prevalence of renal dysfunction was not extensive and furthermore not significantly correlated with haematuria. The associations of further variables with hypertension require future studies to determine causal relationships over time.
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